World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

INVITRO EVALUATION OF MIDOSTAURIN AND ITS DERIVATIVE (O-DESMETHYL MIDOSTAURIN-D5) FOR THE TREATMENT OF ADULT ACUTE MYELOID LEUKEMIA

Dr. Syed Ahmed Hussain*, Farahanaaz Begum, Juveria Gaffar, Shaik Nazma Sultana and Sara Umm E. Hani

ABSTRACT

This research paper presents the results of an experimental study evaluating the effects of O-Desmethyl Midostaurin-D5 on various cellular assays, including MTT, Tubulogenesis, Indirect Immunofluorescence, and Western Blot Analysis. Four groups were analyzed, including normal cells, a control cell line, a group treated with standard Midostaurin, and a group treated with O-Desmethyl Midostaurin-D5. The results reveal varying impacts on cell viability, tubulogenesis, protein expression, and cellular morphology. These findings contribute to the understanding of O-Desmethyl Midostaurin-D5's potential as a therapeutic agent and its implications for further research and clinical applications.

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