World Journal of
Pharmaceutical and Life Sciences

RETROSPECTIVE ANALYSIS OF KERATOCYSTIC ODONTOGENIC TUMOUR IN A COHORT OF SRI LANKAN PATIENTS AND REVIEW OF LITERATURE.

*Dr. Sumith Gunawardane, Dr. Kanchana Kapugama, Dr. Sanjeewa Herath, Dr. Pasan Senevirathna and Prof. Samadara Siriwardena

ABSTRACT

Introduction: Keratocystic Odontogenic Tumour (KCOT) represent 4-10% of all odontogenic tumours and 5% of those cases are involved in nevoid basal cell carcinoma syndrome (NBCCS). Objectives: To investigate the patterns and behavior of KCOT and its association with Gorlin-goltz syndrome in a cohort of Sri Lankan patients. Materials and Methods: A retrospective study was conducted using the cases selected from the archives from 2003 to 2016 Orthokeratinized odontogenic cysts were excluded from the study. The data were presented as means and proportions. Associations were assessed with Fisher's exact test. Results: A significant male predilection was observed (P= 0.033). The male to female ratio is 1.32:1. Age ranged from 7-84 years and the mean age was 35.46 years. Mandible (77.1%) was significantly affected than maxilla (22.1%) (P= 0.001) and only 0.8% occurred in both jaws. Conclusion: The present cohort of KCOTs is the first study in Sri Lanka and some data in par with English literature. As our data indicated high rate of malignant transformation, it is necessary to follow these patients regularly.

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