Abstract
FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF RIZATRIPTAN BENZOATE SUSTAIN RELEASE TABLET DOSAGE FORM
Dasari Poojitha, V. Jhansi Priya Marabathuni* and Naidu Narapusetty
ABSTRACT
The present study was formulation development and in vitro evaluation of rizatriptan benzoate sustain release tablet dosage form. the sustained release tablets containing Rizatriptan Benzoate were prepared by wet granulation method and their evaluation were carried out. The in-vitro drug release studies from the developed formulation F10 was found to be most promising formulation and maintained excellent release of 94.67% up to 12 hrs, extended the duration period. It shows the sustained release characteristics. The formulation F1-F10 follows the release of Higuchi‘s model. The results of the in-vitro release data were fitted to the Korsmeyer Peppa‘s equation, the value of ?n‘ was found to be less than 0.500,indicating the drug release follows Fickian mechanism.
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