World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF ANALGESIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF LUDWIGIA OCTOVALVIS (JACQ.) P.H.RAVEN (ONAGRACEAE) LEAVES IN MICE

Ratovonarindra Kanto*, Andriamampianina Tianarilalaina Tantely, Andriamalala Solofoniaina Gabriel, Rasolohery Claudine Aimée, Quansah Nathaniel and Randrianavony Patricia

ABSTRACT

This study was done to investigate the analgesic activity of Ludwigia octovalvis leaves?extract in Swiss-Albino mice. Peripheral action was assessed by acetic acid-induced writhing method and heat tail-flick test for its central action. Extract was administered orally at doses 100, 200 and 400 mg/kg. In the acetic acid-induced writhing test, the extract in doses of 200 and 400 mg/kg showed 64.63% and 91.67% (p < 0.05) inhibition of writhing, respectively. In heat tail-flick method the extract produced 47.5% and 66.27% elongation of tail flicking time 60 minutes after oral doses of 200 and 400 mg/kg body weight respectively. These results demonstrate the analgesic activity of this plant.

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