World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

COMPARATIVE STUDY OF THE VASODILATORY EFFECT OF THE HEXANIC, DICHLOROMETHANIC, ETHYL ACETATE, BUTANOLIC AND AQUEOUS EXTRACTS OF LUDWIGIA OCTOVALVIS (JACQ.) P.H.RAVEN (ONAGRACEAE)

Ratovonarindra Kanto*, Rasolohery Claudine Aimée, Rakotoarison Olivier, Quansah Nathaniel and Randrianavony Patricia

ABSTRACT

This study aimed to compare vasodilation activity of different extracts of Ludwigia octovalvis prepared using hexane, dichloromethane, ethyl acetate, n-butanol, and water. In vitro tests were performed using isolated aorta of guinea pig pre contracted with norepinephrine. The results of these tests indicate that only the ethyl acetate, nbutanol and aqueous extracts possess vasodilatory activity, with respective EC50 values of 0.45, 0.32 and 0.81 mg/ml. N-butanolic extract is the most active. According to these results, the vasodilator molecules of Ludwigia octovalvis are spread in the ethyl acetate, n-butanol and aqueous extracts, but the most active ones would be in the n-butanolic extract.

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