World Journal of
Pharmaceutical and Life Sciences

CAPSULES: TYPES, MANUFACTURING, FORMULATION, QUALITY CONTROL TESTS, PACKAGING AND STORAGE, INSTRUMENTS-A OVERVIEW ARTICLE

Vetrivel R.*, Sowndarya K., Jothimanivannan C., Gnanavel S., Myvizhikannan R., Nandhakumar D. and Pradeep T.

ABSTRACT

Capsules are solid preparations containing either a soft or hard soluble shell for the drug or excipient. Typically made of gelatin or another suitable polymeric material, the sell produces a straight forward, tasteless, odorless, elegant, and simple dosage form that does not require a secondary coating step. at all medicinal dosage forms, the capsule in solid form has never been the subject of research. In order to accomplish modified drug release, this review incorporates more recent trends in the outer layer of capsules, capsule fill material, a capsule sealing technique, and various capsule systems. When making capsules, the gelatin solution is processed with the help of preservatives and surfactants. Water, which serves as a plasticizing agent for the gelatin coating and is necessary for the function of empty capsules, is present in a significant quantity. The basis of hard capsules is often composed of plasticizer and water. Additionally, the base may include sugars, colours, flavours, and preservatives. The animal source of gelatin can be a problem for certain consumers such as vegetarians or vegans and religious or ethnic groups, Since unmodified gelatin is prone to cross linking when in contact with aldehydes, solubility problems might be expected with certain fill formulations. The non-gelatin capsule shells are made up of such as Starch, HPMC, PVA, and Alginate.

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