World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NEW 2-AMINO-5-ARYL-1,3,4-THIADIAZOLES AS ANTIBACTERIAL AND ANTIFUNGAL AGENTS

A. Aswani*, B. Janaki, G. Hema

ABSTRACT

Thiadiazoles and their analogues exhibit a wide variety of biological activities like antibacterial, antifungal, antitubercular, antidiabetic, anti-inflammatory, anti-convulsant, diuretic etc., In the present research work, some new Thiadiazoles were synthesized from various aryl carboxylic acids with thiosemicarbazide to form various 2-amino-5-aryl-1,3,4-thiadiazole derivatives. The purity of the compounds was identified by TLC and are purified by recrystallization and column chromatography. The structures were determined by IR, 1H NMR and Mass spectral data. The diversified 2-amino-5-aryl-1,3,4-thiadiazoles were screened for their antibacterial (Escherichia coli ATCC 25922), antifungal (Aspergillus niger ATCC 9029) by cup plate diffusion technique. Based on the results of the antitubercular activity SAR of the synthesized compounds is drawn.

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