World Journal of
Pharmaceutical and Life Sciences

ROLE OF PHENOLIC COMPOUNDS IN PREVENTION AND MANAGEMENT OF HUMAN DISEASE

Mahendra Ahirwar, Mahendra Rajput, Maneesh Patel, Manoj Meena, Shikha Mishra*

ABSTRACT

Phenolic compounds represent a group of molecules and its functions in the growth and development with a defense mechanism in plant. It includes pigments, signaling molecules, and flavors which will protect the plant against insects, fungi, bacteria, and viruses and plays a role to attract or repulse them. Inflammation is a natural protective mechanism that occurs when the body’s tissue homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune response generates pro-inflammatory mediators, but excessive output, such as chronic inflammation, contributes to many persistent diseases. Some phenolic compounds work in tandem with nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit pro-inflammatory mediators’ activity or gene expression, including cyclooxygenase (COX). Various phenolic compounds can also act on transcription factors, such as nuclear factor-?B (NF-?B) or nuclear factor-erythroid factor 2-related factor 2 (Nrf-2), to up-or down regulate elements within the antioxidant response pathways. They were having many health benefits like UV screens, attractants, signal compounds, and other response chemicals from different types. As per the human physiology, they are vital in protection and play an important role in prevention and treatment of many chronic diseases. It also acts as antioxidant, antiseptic, anti-proliferative activities, antidiabetic, anti-inflammatory and anti-aging. They are useful to eat such plant foods that contain high antioxidant content, which can hamper the incidence of certain chronic diseases, such as cardiovascular diseases, diabetes and cancers, through the management of oxidative stress. This study also discusses current issues and potential prospects for the therapeutic application of phenolic compounds to various human diseases.

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