World Journal of
Pharmaceutical and Life Sciences

BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES IN ADULT MALE WISTAR RATS FOLLOWING ACUTE ADMINISTRATION OF IBUPROFEN

Okwakpam F.N.*, Omeodu S.I., Nkomadu V.D. and Ajie P.

ABSTRACT

Ibuprofen is a non-steroidal anti-inflammatory drug commonly used worldwide for the treatment of inflammation and pains in man and animals. Despite these benefits, there are concerns that acute administration of this drug may have adverse effect on kidney and liver. More so there are conflicting roles of ibuprofen in pathologies of diseases associated with tissue damage. This study investigated the effect of acute administration of ibuprofen on some biochemical parameter in male albino rats and histological changes in liver and kidney induced by ibuprofen were also investigated. Twenty albino rats were divided into four groups of five animals per group. Group 1 served as control and was given feed and water only. Group 2, 3 and 4 rats were treated with 200mg/kg, 400mg/kg and 500mg/kg ibuprofen orally once a day for 7 days respectively. The result showed that there was a significant (p<0.05) difference in serum creatinine (mg/dl) and serum urea (mg/dl) for Group 2, Group 3 and Group 4 at p?0.05 when compared with group 1 the control rats. More so, there was no significant (p<0.05) difference in total protein (g/L) and total bilirubin (g/L) in all the Groups. There was also a significant (p<0.05) difference in albumin (g/L) in Group 4 only. There was significant (p<0.05) difference in serum Na+ (mg/dl), K+ (mg/dl) and Cl- (mg/dl) for Group 2, Group 3 and Group 4 at p?0.05. Furthermore, Histopathological alterations were found in liver and kidney tissues. Acute Ibuprofen show potentially harmful effect to the liver, kidney and heart of the albino rats.

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