World Journal of
Pharmaceutical and Life Sciences

SOLUBILITY ENHANCEMENT TECHNIQUES

Reshma*, Dr. Osman Ahmed, Syeda Rakhshinda Zareen, Mohammed Sayeed Uddin and Dr. Anas Rasheed

ABSTRACT

The phenomena of solubility, in which a solid dissolves in a liquid to form a uniform system, is known as the phase transition. Solubility is one of the critical parameter to attain required concentration of medication in systemic circulation for pharmacological response to be displayed. Poorly water-soluble medicines may need large dosages in order to attain therapeutic plasma concentrations following oral delivery. Low aqueous solubility is the fundamental difficulty faced with formulation creation of novel chemical entities. Any medicine to be absorbed must be present in the form of an aqueous solution at the site of absorption. Liquid pharmaceutical formulations often use water as their solvent. Most pharmaceuticals have a neutral pH and are hardly soluble in water. Hence different strategies are utilised for the enhancement of the solubility of poorly water-soluble pharmaceuticals including micronization, chemical modification, pH adjustment, solid dispersion, complexation, co?solvency, micellar solubilization, hydrotropy etc. The goal of this review article is to discuss the strategies of solubilizaton for the accomplishment of efficient absorption and increased bioavailability.

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