World Journal of
Pharmaceutical and Life Sciences

SYNTHESIS OF CHALCONE ANALOGUES BY ULTRASONICATION

Chhaya Bhagat and Kundan Tiwari*

ABSTRACT

In this work, an attempt was made to synthesize new chalcones by Claisen - Schmidt condensation of substituted benzaldehydes with 4-aminoacetanilide in the presence of base catalyst. In this study we attempt to change the technique for synthesis of Chalcone, we used utrasonigation method for the same. The synthesized chalcone derivatives were characterized by FT-IR. In a wide search program towards new and efficient antimicrobial agents, substituted chalcones have been synthesized by condensing benzaldehyde derivatives with acetophenone derivatives in dilute Ethanolic sodium hydroxide solution at room temperature according to Claisen – Schmidt condensation. The structures of these compounds have been investigated by infra red spectroscopy.[4]

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