World Journal of
Pharmaceutical and Life Sciences

ISOLATION AND CHARACTERIZATION OF A FALAVANONE FROM SUDANESE DETARIUM SENEGALENSE (J. F. GMEL.) STEM BARK AND BIOLOGICAL ACTIVITY OF DIFFERENT FRACTIONS

Abdel Karim M.* and Sakina A. F.

ABSTRACT

Information on the bioactive constituents of medicinal plants used in Sudanese ethno-medicine is very scarce. Hence,this study was designed to investigate the flavonoids of Detarium senegalense which is widely used by local healers to treat an array of human disorders. Phytochemical screening of Detarium senegalense ethanolic extract revealed the presence of sterols, triterpenes, flavonoids, tannins, saponins, anthraquinones and cyanogenic glycosides. A Flavanone was isolated from stem bark and its structure was partially elucidated on the basis of its spectral data(IR,UV,1HNMR and MS). Different fractions(chloroform, ethyl acetate, n-butanol and ethanol) were evaluated, in vitro, for antimicrobial activity against six standard human pathogens: two Gram positive (Staphylococus aureus and Bacillus subtilis), two Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacteria and two fungal species (Aspergillus niger, Candida albicans) and significant results suggested a rationale for its traditional uses.

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