World Journal of
Pharmaceutical and Life Sciences

ADVANCED INNOVATIVE HYDROGEL OF AMPHOTERICIN B WITH CONJUGATED ALOE VERA GEL FOR FUNGAL INFECTION

Kishori*, U. Fathima Shafika, Fathima Safida, Hamna Shahama and Dr. Ravi Kumar

ABSTRACT

The present work is focused on the development and design of novel Amphotericin-B conjugated along with aloe Vera as Hydrogels to enhance the anti-fungal activity. The Amphotericin -B conjugated Hydrogels are highly soluble in different aqueous solutions because of forming network with biocompatible and biodegradable excipients. The antifungal effect of Am B-conjugated hydrogels significantly exhibits the antifungal activity. The results of the present study indicated that the Am B- conjugated hydrogels are suitable carriers for poorly water-soluble drugs and for enhancement of therapeutic efficacy of antifungal drugs. The effect of aloe Vera gel on appearance, viscosity spreadability, extrudability, drug content uniformity, The Drug content of F3 was found to be 95.38%. In-vitro drug diffusion study of Amphotericin B was investigated. At the end of 7 hrs, Drug released 85.66% when compared with all the other 3 formulations which reveal that increase in the gel concentration will prolong the release of drug which is a favourable condition for fungal infections.

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