World Journal of
Pharmaceutical and Life Sciences

PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF MICROORGANISMS CAUSING URINARY TRACT INFECTIONS IN A TERTIARY CARE FACILITY

Anvi Mardolkar, Vidya Shetty*, Sapna Malik and Jyothirlatha Bangera

ABSTRACT

Background: Urinary tract infection (UTI) represents one of the most common diseases encountered in medical practice today and occurring from neonate to geriatric age group. Urinary tract infection is defined as bacteriuria along with urinary symptoms. It is one of the most common bacterial infections in humans and a major cause of morbidity. UTI has become difficult to treat because of the appearance of pathogens with increasing resistance to antimicrobial agents. The objective of this study was to determine the bacteriological profile of pathogens responsible for urinary tract infection and to assess the antibiotic sensitivity pattern of the causative uropathogens. Material and Methods: 500 urine specimens collected from symptomatic patients were processed for isolation of pathogens and antimicrobial susceptibility by Kirby Bauer disc diffusion method as per CLSI guidelines. Result: Of the 500 samples received 118 yielded culture positive. E.coli was the predominant organism followed by Candida species. UTI was predominant in females. Maximum sensitivity of E.coli was seen with Nitrofurantoin (91.67%), followed by Fosfomycin (86.11%). Candida species showed highest sensitivity to Voriconazole (100%) followed by Nystatin (92.31%) Amphotericin (84.62%). Conclusion: Escherichia coli were a predominant pathogen causing urinary tract infection followed by Candida species. Hence, the aim of this study was to isolate the pathogenic agents involving UTI and to study the antibiotic sensitivity pattern among the samples collected from subjects with clinically suspected infection.

[Full Text Article]   [Download Certificate]