World Journal of
Pharmaceutical and Life Sciences

EFFECT OF METHANOLIC EXTRACT OF PSIDIUM GUAJAVA LEAVES EXTRACT ON PHENYLHYDRAZINE INDUCED ANAEMIA IN ADULT FEMALE WISTAR RAT.

Ijeoma CA., Maduka SO., Meludu SC., *Nnodim JK., Onah CE., Amilo G. and Ezeokafor E.

ABSTRACT

Aim: This study was carried out to determine the potential of methanolic leaf extract of Psidium guajava on phenylhydrazine induced anaemia in adult female wistar rat. Material and Method: Thirty adult female rats weighing between 100g and 110g were assigned into six groups of five rats eat. Group A served as a healthy Control group. Group B, C and D were induced with anaemia using pheylhydrazine intraperitoneally for four days with a dose concentration of 10mg/kg body weight; this was followed by the oral administration of methanolic extract of psidium guajava with a dose concentration of (100mg/kg, 300mg/kg and 500mg/kg body weight) respectively for 14days. Group E was administered with 100mg/kg body weight of the extract only while F received 10g of phenylhydrazine with 500mg/kg body weight of extract simultaneously. Result: The results obtained showed that administration of phenyl hydrazine caused a significant decrease in packed cell volume as well as haemoglobin when compared with the control group (P<0.05). However, on treatment with the methanolic extract of Psidium guajava, the level of PCV and haemoglobin were significantly increased (P<0.05). Conclusion: This observation probably implies that methanolic extract of Psidium guajava could be of benefit in the treatment of anaemia related cases.

[Full Text Article]   [Download Certificate]