Abstract
FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF FLUVASTATIN
*BH. Sriswetha, M. Shiny and G. Edward Raju
ABSTRACT
The current study's goal was to create a sustained release formulation of fluvastatin that would keep the drug's therapeutic levels stable for more than 12 hours. Guar gum, sodium CMC, and hydroxypropyl cellulose are just a few examples of natural polymers that have been used as polymers. The dosage of fluvastatin was set at 20 mg. The tablet's 150 mg total weight was taken into account. There were three different concentrations of polymers used: 25, 50, and 100 mg. Various physicochemical evaluation parameters were applied to all of the formulations, and they were all found to be within acceptable bounds. The formulation (F6), however, demonstrated a better and more desired drug release pattern, i.e., 96.10% in 12 hours, as evidenced by the dissolution studies. It used a release kinetics system of zero order.
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