World Journal of
Pharmaceutical and Life Sciences

DESIGN AND IN-VITRO CHARACTERIZATION OF QUETIAPINE FUMARATE GASTRO RETENTIVE FLOATING TABLETS

Bhogireddi Sriswetha*

ABSTRACT

Atypical antipsychotic drug quetiapine is used to treat schizophrenia, bipolar disorder, and major depressive disorder. Due to its sedative effect, it is frequently used as a sleep aid, however the advantages of doing so do not always seem to outweigh the drawbacks. It's consumed orally. The object of the present work is preparing Quetiapine fumarate gastro retentive floating tablets. With changing amounts of retardation polymers, the gas producing agent accrual was introduced at various concentrations. Carbopol 971, Carbopol L934P and HPMCK100M were used as polymers for retardation. The formulation blend's various physicochemical properties were assessed, and all the parameters were found to be within the acceptable ranges. The formulations. F1-F9 were developed, and several quality control criteria were used to evaluate them. The formulations were developed, and several quality control criteria were used to evaluate them. According to the dissolution results, formulation F8 was the best, with a maximum percent drug release of 97.81% and a floating time of 12 hours.

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