World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF ETHANOLIC EXTRACT OF ROOTS OF TRIANTHEMA TRIQUETRA FOR ANTI-ULCER ACTIVITY IN ALBINO RATS

Syed Safiullah Ghori* and Tahmeena Humaira

ABSTRACT

The aim of the present investigation was to evaluate the antiulcer activity of Trianthema triquetra roots ethanolic extract in Wistar albino rats using NSAIDs & Ethanol induced ulcer models. Plant material was collected from Tirupati A.P, during the month of June 2014. The roots were made free from dust and foreign material and dried under shade at room temperature. After a week the roots were powdered and passed through a sieve. The powder was weighed (500 gm) and was extracted by successive solvent extraction process. The yield of ethanolic extract of trianthema triquetra was found to be 7.31% W/W. Phytochemical screening was carried out for the detection of the phytoconstituents by simple qualitative methods. The dosing was designed as per the acute toxicity study reported earlier. The anti-ulcer activity was performed by NSAID and ethanol induced ulcer model at two different doses, 200mg/kg and 400mg/kg. Wistar rats weighing(130-150gm) of either sex were used for the study. There was significant reduction of ulcers in the test groups observed in both NSAID and ethanol induced ulcer models. TTEE exhibited anti-ulcer activity in both curative and prophylactic experimental models which provides the evidence of its use as a potent anti ulcer drug.

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