Abstract
FORMULATION AND EVALUTION OF TELMISARTAN FAST DISSOLVING TABLET BY DIRECT COMPRESSION METHOD
Bagwan Wasim*, Bagwan Jasmin, Khan Juber, Shaikh Shehzad, Shaikh Aaqueeb and Dr. G. J. Khan
ABSTRACT
Telmisartan is an ACE inhibitor anti-hypertensive drugs which is insoluble in water, hence the drug may be slowly or incompletely dissolves in the gastro-intestinal tract. So, the rate of dissolution and therefore its bioavailability is less (bioavailability 42%). In the present study an attempt has been made to prepare Fast Dissolving tablets of Telmisartan by using Super disintegrants to increase the rate of drug release from dosage form to increase the dissolution rate and hence its bioavailability. The tablets were prepared by Direct Compression methods and the prepared blend and tablets were evaluated for their physicochemical properties and In-vitro dissolution study. The Disintegration time of Fast Dissolving tablets were increased by the addition of concentration of super disintegrants.
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