World Journal of
Pharmaceutical and Life Sciences

STUDIES ON FORMULATION AND EVALUATION OF ACECLOFENAC MATRIX DRUG DELIVERY SYSTEM USING A NATURAL GUM FOUND IN SATPUDA REGION OF NORTH MAHARASHTRA

*Jayesh M. Rajput, Dhanshri S. Nandre, Bhagyashri G. Pawar and Bhagyashri J Jayswal

ABSTRACT

Aceclofenac is an NSAID (Non-Steroidal Anti-Inflammatory class drug) it is an analogue of Diclofenac, many researchers developed Aceclofenac matrix dosage form which are capable of providing a prolonged therapeutic effect. But, in this formulation Aceclofenac is combined with a Natural polymer and also with a Synthetic polymer, for Synthetic polymer HPMC K200M were preferred and for Natural polymer a Natural gum specially from the region of North Maharashtra mountain ranges also known as “Satpuda” ranges a gum were collected known as “Guggul Gum” which has a good binding ability and itself has many therapeutic properties like Anti- Inflammatory, Anti-Bacterial which can increase the therapeutic effect of formulation and which can help in increasing the period of Half-life or storage of the formulation. It has good binding abilities so, can also be used as a Natural Binder. In this study the formulation was developed as a matrix dosage system in an oral tablet form with a dose of 300 mg/Tablet and formulations were made by Factorially designed.

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