World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF NEUROLEPTIC POTENTIAL OF HYDROALCOHOLIC LEAVES EXTRACT (HLE) OF AZADIRACHTA INDICA (NEEM) IN ALBINO RATS

*Najeebullah, N. Trilochana and Ashutosh Yadav

ABSTRACT

Psychosis is a term used to describe disorders that affect the mind and create a loss of contact with reality. Women are 1.5-2 times more likely than men to suffer from anxiety disorders. Present study was based on evaluation of neuroprotective effect of hydroalcoholic leaves extract (HLE) of A. indica in Wistar albino rats by using diverse types of animal models to confirm its actual pharmacological potential. Leaves of M. indica was obtained from the Unnao reason. It was identified and authenticated by a botanist and extracted by percolation process. Rats were divided into group 1 (normal saline), group 2 (Apomorphine 5 mg/kg), group 3 (Pregabalin (10mg/kg), group 4a & 4b (Aq. AI leaves extract- 200mg/kg & 400mg/kg), group 5a & 5b (Eth. AI leaves extract- 200mg/kg & 400mg/kg) and group 6a & 6b (Meth. AI leaves extract- 200mg/kg & 400mg/kg). Different parameters were evaluated i.e., Apomorphine-induced stereotypy, Haloperidol induced-catalepsy, Climbing behavior and Neurotransmitter measurements. In results, it significantly decreased the climbing behavior, stereotyped behavior and elevated levels of neurotransmitters in rats. It concludes that AI has potential neuroprotective behaviour at the all the doses used but highest was observed in ethanolic extract- might be due to better solubility and constituents release from the A. indica leaves in percolation. Future research suggests, to identify and isolate the responsible element for the pharmacological potential and make the suitable dosage form the make available in the market and society in the cure of this deadly affective mental disorder.

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