World Journal of
Pharmaceutical and Life Sciences

STUDIES ON BIODEGRADABLE IMPLANTABLE DRUG DELIVERY DEVICE OF MELOXICAM FOR POST OPERATIVE ANIMAL CARE

Sanjeev L. Gupta*, G. V. Suresh Kumar and Lingaraj S. Danki

ABSTRACT

Post operative surgical care of a orthopedic patient is utmost important for speedy recovery from injuries. Subcutaneous implantation is currently the most utilized route of the potential of controlled drug delivery system. Present investigation attempts to prepare biodegradable subcutaneous implants of Meloxicam, a nonsteroidal anti-inflammatory agent used in treatment of orthopaedic patient care. Implant formulated with 30%W/W Gelatin by heating and congealing method. The implants were evaluated for content uniformity, thickness, weight variation, IR, in vitro release studies and stability studies at ambient temperature for 3 months showed there were no changes in appearance and the in-vitro drug release rates. Implants were found to erode slowly with diffusion mechanism. In vivo studies in sheep revealed that at subdermal thigh region before and after one month of Implantation of polymeric rod, there was no inflammation at the site of implantation, foreign body grannuloma formation, necrosis or hemorrhage.

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