World Journal of
Pharmaceutical and Life Sciences

ANTIMICROBIAL STUDY OF KUTAJADI CHURNA AND KUTAJADI SUSPENSION: AN IN-VITRO STUDY

Aiswarya Babu and R. S. Hiremath*

ABSTRACT

Introduction: Diarrhoea affects 3-5 billion people globally each year, causing 5 million deaths especially children under 5 years. The major causative agents of diarrhea include a variety of enteric pathogenic bacteria. Kutajadi churna is an unexplored polyherbal ayurvedic formulation which is indicated for raktatisara (bloody diarrhea). Kutajadi suspension is the modified form of kutajadi churna aiming better ease of administration, longer shelf life and bioavailability. Aim: To study the antimicrobial activity of Kutajadi churna and Kutajadi suspension. Methodology: Agar well diffusion and Broth dilution method were carried out as per the standards for testing. Result: Kutajadi churna shown presence metabolites like tannins, saponins, flavanoids etc which are responsible for antimicrobial, antidiarrheal, antioxidant activity. Kutajadi churna shown no growth for E. coli (2 lac ppm), S. typhi (2 lac and 1 lac ppm), S. flexineri (2 lac and 1 lac ppm), S. aureus (2 lac,1 lac and 50,000 ppm). Kutajadi suspension shown no growth for E. coli, S. typhi, S. flexineri and S. aureus (20 lac ppm). Conclusion: The Kutajadi churna and Kutajadi suspension possess antimicrobial activity against E. coli, S. typhi, S. flexineri, and S. aureus at various concentrations.

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