World Journal of
Pharmaceutical and Life Sciences

IN SILICO EVALUATION FOR GLUCOKINASE SENSITIZER OF SOME NOVEL LIGNANDS AS POTENTIAL ANTIHYPERGLYCEMIC AGENTS

Mrityunjay Banerjee*, Rasmi Ranjan Biswakarma, Sahin Meheboob and Sujit Kumar Sahu

ABSTRACT

Glucokinase could indeed serve as pacemaker of glycolysis & could be an attractive target for type-2 diabetes. Binding modes of a series of Some Novel Lignands as protein Glucokinase (Hexokinase 4) (PDB ID:1V4S) Sensitizer have been identified by molecular modeling techniques. We have performed docking and ADME predictions of this Sensitizer with Hexokinase 4 enzyme. ADME predictions of 6 top selected compounds were done with Medchem desiner with version 2.0. The results indicate that Protein-ligand interactions were studied using Glucokinase protein PDB ID1V4S, obtained from Protein data bank to evaluate the affinity of various Glucokinase modulating analogues towards ligand binding site and to study the extent of correlation between experimental values and computational dock scores, to proposed a new compounds with Glibenclamide, Glipizide, Glimipiride, Gliclazide as the standard. The information generated from the present study should be useful in the design of more potent Glucokinase (Hexokinase 4) (PDB ID:1V4S) Sensitizer as antidiabetic agents.

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