World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND CYTOTOXIC ACTIVITY OF CLERODENDRUM SIPHONANTHUS

Subhashree Mohapatra and Sunita Bhatnagar*

ABSTRACT

Four solvent leaf extracts of Clerodendrum siphonanthus were prepared and their phytochemical, Antioxidant and Cytotoxic activities was evaluated. Solvent extracts showed the presence of Tannins and Alkaloids. Qualitative and quantitative antioxidant assay was carried out by using TLC based antioxidant assay and DPPH free radical scavenging assay, Ferric reducing anti–oxidant power assay (frap assay) respectively. In TLC based antioxidant assay most of the bands observed in chloroform extract followed by ethyl acetate and Methanol extracts in BEA solvent. In FRAP assay, ethyl acetate and Methanol extracts exhibited mild activity. In DPPH assay ethyl acetate and chloroform extract have effective antioxidant activity. Hexane extract showed cytotoxic potential with 100% activity at highest dose administered.

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