World Journal of
Pharmaceutical and Life Sciences

CHRONIC LYMPHOPROLIFERATIVE SYNDROMES: A STUDY OF 99 CASES

*Dr. Raja Nakhli, Ghita Elghouat, Hicham Yahyaoui and Mohamed Chakour

ABSTRACT

Introduction: Chronic lymphoproliferative disorders (CLPD) are an heterogeneous group of diseases characterized by uncontroled production of lymphocytes that cause clonal lymphocytosis, lymphadenopathy, and bone marrow infiltration. Methods: A retrospective analysis (2014 to 2020) was carried out on the basis of 99 patients with lymphoproliferative disorders in the Laboratory of hematology of the Avicenne military hospital in Marrakech to describe the epidemiological, clinical, cytological characteristics of lymphoproliferative disorders. Results: Among 99 registered cases, there were 62 cases of multiple myeloma (MM) (62,62 %), 32 cases of chronic lymphoid leukemia (CLL) (32,3%), 3 cases of Sézary syndrome (SS) (3 %), a single case of Hairy Cells Leukemia (HCL) (1%) and a single case of prolymphocytic leukemia(LPB) (1%) were described. The median age of the patients was 61 (range: 41 to 80) years. There were 76 males (76%) and 23 females (24%), Male-to-female sex ratio was 3. Myelomas are the most frequently encountered in our series,bone pain is present in 78% of multiple myeloma patients, 6% have vertebral compression and 7% present chronic renal failure. Monoclonal gammopathy with kappa-type IgG is found in 60% of cases, IgG lambda in 26% of cases, IgA kappa in 5% of cases, IgM kappa in 4% of cases, and kappa light chains in 5% of cases.We found 32 cases of CLL, the average age is 65 years with extremes ranging from 45 to 78 years with a sex ratio of 5. Peripheral lymphadenopathy is the most frequent revealing symptom of the disease in 31 cases (50%) associated with splenomegaly in 2 cases, 45 % of cases were clinically asymptomatic. Conclusions: This retrospective study provides a clinical, epidemiological and cytological description of lymphoproliferative disorders in 101 cases

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