World Journal of
Pharmaceutical and Life Sciences

MICROSPHERES AS DRUG CARRIERS – AN OVERVIEW

Reeta Shakya*, Suman Jain and Sunisha Kulkarni

ABSTRACT

Oral modified-release multiple-unit dosage forms have always been more effective therapeutic alternative to conventional or immediate release single-unit dosage forms. Novel drug delivery systems have several advantages over conventional multi dose therapy. Recent trends indicate that micro particulate drug delivery systems are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time. Microspheres received much attention not only for prolonged release, but also for targeting of drugs. Micro particulate drug delivery systems provide tremendous opportunities for designing new controlled and delayed release oral formulations, thus extending the frontier of future pharmaceutical development. In future microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, genetic materials, and targeted and effective drug delivery. The current aim of this review is to study various aspects of the micro particulates drug delivery system including method of formulation, evaluation & characterization. Microspheres received much attention not only for prolonged release but also for targeting of anticancer drugs to the tumor.

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