World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND EVALUATION OF TASTE-MASKED AZITHROMYCIN READY-MIX ORAL SUSPENSION

Ibaa K. I. Hag-Ali* and Ali Elmardi M. Hussein

ABSTRACT

Azithromycin, the macrolide antibiotic, is an azalide derived from erythromycin having bactericidal and bacteriostatic activity by inhibiting the mRNA of the bacteria. It is characterized by its bitter taste which is intensified by the amide group which limits its use for children as the oral liquid form is the most favorable form. The taste can be masked by different techniques and materials of which is the ion-exchange resin, flavors and adsorbing agents. The excipients used to prepare the oral suspension were subjected to compatibility testing and solubility testing then five formulations were designed altering the ion-exchange resin; Kyron T-112 and Magnesium Oxide as a taste adsorbent. Ten healthy volunteers evaluated the taste for each formula. Then the optimized formulation was compared to an imported marketed brand for the taste where the bitterness disappeared, the physical properties are similar to the latter formulations. The maximum drug release percentage is 100.47% in 45 mins which is superior to the market brand and the active ingredient content per volume was 99.31%. It is concluded that, Light Magnesium Oxide efficiently masked the taste of azithromycin in oral liquid suspensions.

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