World Journal of
Pharmaceutical and Life Sciences

PHYTOREMEDIAL EFFECT OF WITHANIA SOMNIFERA AGAINST ENDOSULFAN INDUCED TOXICITY IN SERTOLI CELLS OF MICE

Basant Kumar*, Arun Kumar, Mohammad Ali and Ranjit Kumar

ABSTRACT

The main objective of the study was to observe the ameliorative effect of Withania somnifera on Endosulfan induced toxicity in sertoli cells of mice. In the present study, Endosulfan at the dose of 3mg/Kg body weight was administered orally to male mice for 5 weeks. Thereafter, crude root extract of Withania somnifera at the dose of 800 mg/Kg body weight was administered for 5 weeks to observe the ameliorative effect of it on sertoli cells. The study reveals that after the administration of Endosulfan, there significant damage at the sub cellular level in sertoli cells of mice. There were significant changes in the testosterone level in endosulfan exposed group. Administration of Withania somnifera, caused significant reversal at the sub cellular levels denotes that it not only possesses antioxidant and rejuvenating property but also maintains the cellular integrity and ultrastructure of sertoli cells. Testosterone levels were also restored effectively in withania administered group. It is one of the best antidote against endosulfan induced sub cellular toxicity.

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