World Journal of
Pharmaceutical and Life Sciences

SPHINGOSOMES: HIGHLIGHTS OF THE PROGRESSIVE JOURNEY AND THEIR APPLICATION PERSPECTIVES IN MODERN DRUG DELIVERY

Madhukar Shende*, Prashant Dnyaneshwar Ghode, Shweta Ghode, Satish Bodele, Aparna Shende and Nilesh Ashokrao Nalawade

ABSTRACT

Introduction: In a variety of scientific fields, vesicular systems have shown to be very effective carrier systems. Sphingosomes are bilayered vesicles with an aqueous volume completely contained by a membrane lipid bilayer mostly made up of natural or synthesized sphingolipid. Sphingosomes address some of the main flaws in the vesicle system (liposomes, niosomes), such as instability, in vivo circulation time, and tumor loading effectiveness in cancer treatment. Method: The literature was collected from Google Scholar and Scopus database with keyword of Sphingosomes. Result: Clinically, sphingosomes are utilized to transport chemotherapeutic agents, biological macromolecules, and diagnostics. Different kinds of sphingosomes have been created as a result of their size and composition flexibility. Conclusion: Sphingosomes are a potential vesicular drug delivery system that may transport medicinal chemicals for a variety of uses, according to the findings of this review.

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