World Journal of
Pharmaceutical and Life Sciences

FORMULATION OF A POLYHERBAL CREAM AND SCREENING FOR ITS ANTI-INFLAMMATORY ACTIVITY

M.S. Riyazullah*, Kavitha S. and M. Ravi

ABSTRACT

The present study has been undertaken with the aim to formulate and evaluate the polyherbal crem containing Curcuma longa Linn., and Zingiber officinale extract. The polyherbal formulation was designed by using methanolic extract of Rhizomes of Curcuma longa and Zingiber officinale in varied concentrations (2 and 4%). Topical anti-inflammatory activity of gel was also evaluated. The herbal cream was prepared by using olive oil and bees wax as cream base, The prepared herbal cream were evaluated for physical appearance, pH, spreadability, skin irritation to observe toxicity or side effects and also for anti inflammatory activity. It was inferred from the results that cream formulations were good in appearance and homogeneity. The values of spreadability indicated that these polyherbal cream were easily spread able by small amount of shear. Viscosity of polyherbal cream were determined by using Brookfield viscometer and were ranging between 4500 to 4900 centipoise. The gels showed significant inhibition in carrageenan induced paw oedema and formalin induced paw oedema in Wistar rat models.

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