World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF REPAGLINIDE

M. Mohan Varma and Indukuri Kinnera*

ABSTRACT

Repaglinide is a novel oral hypoglycaemic agent chemically unrelated to the sulphonyl urea's, metformin or Acarbose. Repaglinide stimulates the release of insulin from pancreatic beta-cells by inhibition of potassium efflux resulting in closure of ATP regulated K+ channels thus the main objective of sustained release drug delivery systems was to ensure safety and to improve efficacy of drugs as well as patient compliance. To increase the stay period of drug in its absorption area and decrease the dosing interval by increasing the bio availability. Sustained release tablets were prepared by direct compression technique using polymer like HPMC, Carbopol, PEG (Polyethylene glycol enhances the solubility of the drug in the water, therefore enhancing the dissolution rate and bio availability) in different ratios. It was also concluded that the formulations which contains only HPMC & Carbopol was more promising in modifying the drug release pattern as compared to the other formulations. Amongst the 8 formulations, formulation F4 was found to be most promising formulation. Because it has shown most consistent drug release (97.4%) at the end of 20 hours as compared to remaining formulations as well as formulation F4 showed. As the drug release was best fitted in First order kinetics, indicating that the rate of drug release is concentration dependent.

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