World Journal of
Pharmaceutical and Life Sciences

STUDY OF VITAMIN D AND FERRITIN LEVELS IN SARS-COV-2 POSITIVE PATIENTS BY PCR AND THEIR RELATIONSHIP WITH THE ANTIBODY INDEX IgG.

Angel San Miguel Hernández*, María San Miguel Rodríguez, Julia San Miguel Rodríguez and Angel San Miguel Rodríguez

ABSTRACT

Currently, it is stated that patients with Covid-19 have low levels of vitamin D and high levels of ferritin in some of the phases of their disease. Vitamin D levels have been studied in 159 patients who initially tested positive for SARS-CoV-2 PCR and whose level of IgG antibodies to SARS-CoV-2 was measured in order to calculate their e index. try to see the relationship with vitamin D levels. The mean of the index values found against the IgG antibodies against SARS-CoV-2 of the 159 patients studied presented a value of 5.14 ±2.22. We have also observed that the mean of the vitamin D values found in these same patients presented a value of 19.7±8.3 ug/L. And the mean of the ferritin values found in the 91 patients presented a value of 956.6 ±405.2 ng/ml, with normal values in our laboratory of 10-120 ng/ml. In our study, we did not find statistically significant differences when comparing vitamin D levels with the SARS-CoV-2 antibody index by linear regression in the 159 patients studied (p > 0.05). Although we have observed in our case, that there is an important group of patients who have the highest levels of Vitamin D, with the lowest levels of antibodies against SARS-CoV-2, but without finding statistically significant differences. Nor have we found statistically significant differences when comparing ferritin levels with the SARS-CoV-2 antibody index, in the 91 patients studied (p > 0.05). Not even when we compared vitamin D levels with ferritin levels, we could not find significant differences in their correlation either. This could be due to the fact that our patients studied were not stratified according to clinical severity and were patients who were in hospitalization and in the ICU and in different phases of the disease. Covid-19 patients with lower vitamin D levels also have elevated serum levels of inflammatory markers such as ferritin and other markers. So if the treatment with vitamin D plays a role in the prevention of the disease or in the improvement of the prognosis of patients with Covid-19; this will have to be elucidated in large randomized controlled trials, as these studies are necessary to precisely define the role of supplementation with this vitamin in future waves of SARS-CoV-2 infection.

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