World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

PHARMACOLOGICAL SCREENING OF ETHANOLIC FLOWER EXTRACT OF COUROUPITA GUIANENSIS FOR ITS ANTI- ULCER ACTIVITY

Lalitha V., Mohamed Fiaz A.* and Manickavalli E.

ABSTRACT

The antiulcer Potential of ethanolic flower extract of Couroupita guianensis (EFCG) was investigated in indomethacin plus pylorus ligation induced gastric ulcer model in experimental rats. Ethanolic flower extract of Couroupita guianensis at a dose of (200 and 400 mg/kg) produced significant inhibition of the gastric lesions induced by indomethacin plus pylorus ligation induced gastric ulcer. The extract (200mg/kg and 400mg/kg) showed significant (p<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. The present study indicates that EFCG have potential anti-ulcer activity in indomethacin plus pylorus ligation induced gastric ulcer model. These results may further suggest that the extract was found to possess anti-ulcerogenic activity which might be due to the presence of phenolic compounds.

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