World Journal of
Pharmaceutical and Life Sciences

CONSTITUENTS AND ANTIMICROBIAL ACTIVITY OF SUDANESE GREWIA VILLOSA (TILIACEAE) OIL

Prof. Abdel Karim M.*, Mazin I., M. Alla and Magid T.

ABSTRACT

Grewia villosa is a shrub which is distributed in Africa and India usually in arid areas. This shrub is often growing on river banks liable to flooding or on shade of larger trees. In Sudan the fruits are marketed as a fermented drink. In its native range leaves are considered as a good livestock fodder. Grewia villosa root is antidiarrhoeal. It is also used against cough. A mixture of root and bark is used traditionally against syphilis, In this study, Grewia villosa oil has been analyzed by GC-MS. The analysis showed 21 components. Major constituents are: i)9, 12-octadecadienoic acid (Z, Z)-, methyl ester( 48.65%) ii)- hexadecanoic acid, methyl ester(18.33%). iii)9-octadecenoic acid (Z)-, methyl ester (16.15%). iv)- methyl stearate (9.45%) The antmicrobial activity of the oil has been assessed. The studied oil showed significant activity against Klebsiella pneumoniae. However, it failed to exhibit activity against other test organisms.

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