World Journal of
Pharmaceutical and Life Sciences

ISOLATION, PARTIAL CHARACTERIZATION OF A DIHYDROCHALCONE FROM SUDANESE SOLANUM DUBIUM LEAF (GUBBAIN) AND BIOLOGICAL ACTIVITY OF THE METHANOL EXTRACT

Athar M. H., Affaf M., Ragga S. M. and Abdel Karim M.*

ABSTRACT

Plants contain many bioactive molecules such as flavonoids, alkaloids and steroids that produce beneficial physiological and biochemical actions in the human body. The presence of such molecules in Solanum dubuim was evidenced by a phytochemical screening of Solanum dubuim leaves which revealed the presence of flavonoids, alkaloids, tannins, steroids and saponins. In this study a flavonoid -compound(I)- was isolated from the methanol extract of Solanum dubuim leaves by thin layer chromatography and its structure was partly characterized on the basis of its spectral data (UV,NMR). The methanol extract of Solanum dubuim was evaluated for antioxidant activity. In the DPPH assay, the methanol extract exhibited significant free radical scavenging capacity.

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