World Journal of
Pharmaceutical and Life Sciences

REVITALIZATION OF ANTIOXIDANT ENZYMES BY RED GRAPE SEED EXTRACT (RGSE) DUE TO D-GALACTOSE INDUCED CHANGES ON ALZHEIMER’S DISEASE (AD) IN MALE ALBINO RATS

V. Uday Kiran, S. Allabakash, Dr. K. Peera and *Prof. K. Yellamma

ABSTRACT

Neurodegenerative and terminal disease was first discovered by German psychiatrist and neuropathologist Alois Alzheimer in 1906 and was named after him. Generally, it is diagnosed in people over 65 years of age. In this study, the protective role of grape seed extract against D-Galactose dose-induced neural toxicity has been evaluated. The present study was carried out on the male albino rat, Age matched rats were be divided into 4 groups of six in each group and treated as follows: Group-I.Control (C) rats received 0.9% saline. Group-II. Rats treated with intraperitonealy (IP) administered with D-Gal (120 mg/kg body weight) up to end of the experiment (1st day to 90th day).Group-III. Rats treated orally administered with Red grape seed (GSE) ethanol extract (100mg/kg body weight) for 60 days. Group-IV. Rats were treated with intraperitonealy injected with D-Gal (120 mg/kg body weight) once daily for first 30 days. From 31stday onwards rats were administered with Red grape seed ethanol extract (100mg/kg body weight) for 30 days. The animals were sacrificed on 60thday of experimentation by cervical dislocation. Isolated the Brain tissue and measured the activity levels of Superoxidedismutase (SOD), Catalase (CAT), and Lipid Peroxidation (LPO). In the present study Data showed that AD induced rats treated with D-Gal showed maximum SOD levels in the brain tissue. Mean while SOD activity were significantly elevated in AD induced rats with RGSE (AD+RGSE). CAT activity were found in AD induced rat brain and considerable inhibitions was noticed, in AD induce rats treated with D-Gal. Catalase levels were significantly decreased in GSE. LPO levels were decreased in the AD induced rats treated with D-Gal, LPO levels were significantly increased in GSE alone treated and AD induced rats treated with RGSE. This study provides a new approach for the dealing of AD or, may at least improve the quality of life of patients with AD.

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