World Journal of
Pharmaceutical and Life Sciences

POTENTIAL ROLES OF AQUEOUS AND ORGANIC EXTRACTS OF ZIZIPHUS JUJUBA AS AN ANTI-BACTERIAL AND ANTI-OXIDANT AGENT

Mansoor Shazia* and Mustafa Huma

ABSTRACT

Ziziphus jujuba is an economically important tropical fruit tree, which is grown all over the dry parts of the Indian sub-continent. The aim of the study was to examine anti-microbial and anti-oxidant property in leaf extract of Z. jujuba extract (aqueous, cyclohexane, benzene, chloroform, acetone, ethyl acetate, ethanol and methanol). The methanollic extract showed considerable anti-microbial activity against S. aureus and the zone of inhibition was found to be 18 mm and 15 mm at the concentration of 40 mg/ml concentration of plant extract by well and disc diffusion method respectively. The anti-oxidant activity by different methods were screened and the strongest activity were shown by methanol extract and gave IC50 value of 134.6 ± 0 ?g/ml by DPPH method. The IC50 value of 26.07 ± 2.75 ?g/ml and 43.2 ± 1.55 ?g/ml were obtained in methanollic extract by Alkaline DMSO and Nitric oxide scavenging assay respectively. Whereas, hydroxyl radicals were strongly scavenged by benzene extract and gave IC50 value of 18.3 ± 11.51 ?g/ml.

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