World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

A REVIEW ON VARIOUS METHODS TO ENHANCE THE SOLUBILITY AND BIOAVAILABILITY OF DRUGS

K. Sireesha* and Amulya C. H.

ABSTRACT

Solubility is one of the important parameters to achieve the requiredconcentration of drug in systemic circulation for getting the pharmacological actions. The poor solubility and low dissolution rate of poorly soluble drugs causes’ insufficient bioavailability in gastrointestinal fluids. Many pharmaceutical techniques have been developed to increase the solubility of drugs thereby enhancing their bioavailability. Each technique has own advantages and disadvantages. Knowledge of factors influencingsolubility and dissolution of drugs helps in developing new methods to enhance bioavailability of drugs.

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