World Journal of
Pharmaceutical and Life Sciences

RECENT UPDATE IN THE MANAGEMENT OF ORAL COMPLICATIONS FOLLOWING CHEMOTHERAPY IN ACUTE LYMPHOBLASTIC LEUKEMIA

*Dr. Md. Golam Hafiz, Professor Dr. Chowdhury Yakub Jamal and Professor Dr. Afiqul Islam

ABSTRACT

Mucositis is an unavoidable oral complication during chemotherapy in acute lymphoblastic leukemia. It decreases pH of saliva thereby increases oral infections. Chlorhexidine mouth wash, fluoride toothpaste prevents these complications. Zinc helps in mucous membrane stabilization; regulate taste perception having cofactor alkaline phosphatase within taste bud membrane. Dry mouth, decrease salivation is prevented by sibs of water, chewing gum, and cholinergic drugs. Leukemic children should rinse their mouth with baking soda for cleaning and lubrication. Benzydamine hydrochloride mouth wash prevents dental caries, xerostomia, and mucositis. Ice chips decreases poor entry of drugs to oral mucosa, vasoconstriction, poor blood flow, reduces severity of mucositis. Growth factors stimulate epithelial cell proliferation, decrease mucositis. Sucralfate checks oral infections and pain. Oral exercises are helpful to prevent trismus in leukemic children. Low dose laser therapy may be a choice to prevents secondary infections. Amifostine, Topical Vitamin E, Topical Beta-carotene, Prostaglandin E Lozenge, Glutamine, Granulocyte Colony Stimulating Factor provides a temporary physical barrier or lubricating agents.

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