World Journal of
Pharmaceutical and Life Sciences

A COMPARATIVE STUDY TO EVALUATE HEPATO AND UTERO PROTECTIVE ROLE OF ALOE VERA AND VITAMIN E IN ETHANOL FED OVARIECTOMIZED RATS

Maitryee Banerjee, Rafi Ahammed Reja, Purba Ganguly and Nirmal Pradhan*

ABSTRACT

Vitamin E and Aloe vera have been attributed with a plethora of health promoting actions. The purpose of this study was to evaluate the hepatic and utero protective role of Aloe vera and vitamin E in ethanol fed bilateral ovariectomized rats. Experiments were carried out in different groups – a. Sham operated control (SOC), b. Control (c) + E (Ethanol), c. Ovariectomized (O), d. O+E, e. O + E + Vit-E, and f. O + E + A (Aloe Vera). In this study of consicutive 30 days, significant hepatic damage was observed in bilateral ovariectomized rats treated with ethanol (0.5ml, 15% v/v /100g b.wt. /day) as reflected in their altered serum AST(SGOT), ALT(SGPT) and ALKP activity. Also, uterine regression was confirmed in these group of rats by significant lowered uterine protein content and decreased activity of uterine AST, ALT, and ALKP activity. Vitamin E supplementation (10mg in 0.5ml olive oil /100g b. wt. /day), apart from it’s unique influence in preventing hepatic damage, also could prevent ethanol induced uterine regression in ethanol fed bilateral ovariectomized rats. Comparatively Aloe Vera supplementation (30mg in 0.5ml distilled water /100g b. wt. /day) also prevents hepatic damage lesser than vitamin E but could prevent ethanol induced uterine regression in ethanol fed bilateral ovariectomized rats quite greater than Vitamin E.

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