World Journal of
Pharmaceutical and Life Sciences

FISSION YEAST SCHIZOSACCHAROMYCES POMBE AS A FOREIGN-GENE EXPRESSION SYSTEM

Nipunjot Kaur Soni-Bains*

ABSTRACT

The expression and the production of proteins of interest are important for both basic research, and practical applications. Hence, the demand for foreign-gene expression systems is increasing rapidly. Many kinds of foreign-gene expression systems have been developed, some using Escherichia coli as a host, and others using Bacillus, Streptomyces, Aspergillus, yeast, insect cells, plant cells and mammalian cells. A number of these systems are used for industrial applications such as the production of pharmaceuticals and enzymes. Fission yeast Schizosaccharomyces pombe, is discussed here as host model for high-level protein production and functional analysis of eukaryotic proteins as it shares many molecular, genetic and biochemical features with higher eukaryotes. The review summarizes the use of S. pombe as foreign-gene expression system.

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