World Journal of
Pharmaceutical and Life Sciences

MATRIX ASSISTED CO CRYSTALLIZATION OF ACETAZOLAMIDE FOR ENHANCING AQUEOUS AND LIPIDIC SOLUBILITY

Dhanashree Vithal Halbe*

ABSTRACT

Pharmaceutical Science nowadays is an emerging field to serve mankind and consists of challenges to produce efficient and optimized medicines. The concept of enhancing a drug’s efficacy depends upon many factors such as pharmacokinetics, pharmacodynamics of the drug, which again depend upon physicochemical properties of that drug. The therapeutic knowhow of the drug is not enough to prove the reliability of the drug. Many parameters are taken into consideration to formulate market ready drug. Solubility, Permeability are among them who play an important role in Bioavailability of the drug. New approach available for the enhancement of drug solubility is through the application of the co-crystals, it is also referred as molecular complexes. A novel method for the simultaneous production and formulation of pharmaceutical cocrystals, matrix-assisted cocrystallization (MAC), is presented considering Acetazolamide, a BCS Class IV drug with utmost difficulty in formulation and has greater solubility issues. This article focuses on the study of cocrystallization of Acetazolamide using suitable coformer and a matrix for stability commonly referred as MAC product which will be prepared by the ball milling of the three components. The main aim is to produce scalable, amenable method of production of cocrystals and enhancing solubility.

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