World Journal of
Pharmaceutical and Life Sciences

HYPOGLYCERMIA AND SERUM BIOCHEMISTRY: ROOT AND LEAF COMBINATION OF COMBRETUM HISPIDUM. LAW EXTRACT ON ALLOXAN INDUCED DIABETES IN RATS

O. V. Ikpeazu*, K. K. Igwe and I. E. Otuokere

ABSTRACT

Antidiabetic activity of Combretum hispidum and Biochemical indices was checked. Twenty-five rats were used for the research were grouped into five of five rats each. Groups 1 was the untreated diabetic group, 2, 3 and 4 were the treated groups which received equal doses of root and leaf extract at 100 +100, 200+200 and 400+400 mg/kg body weight of the C. hispidum, extracts. Group 5 was the positive control and was administered known antidiabetic drug Glibenclamide. Diabetes was induced in the rats with alloxan monohydrate. C. hispidum, extract was administered to rats for 14 days orally by intubation, thereafter were sacrificed and blood collected from heart for analysis. Effect of C. hispidum, extract was checked on blood glucose level and serum biochemistry. All results in treatment groups were compared with the untreated diabetic group at statistical confidence of p<0.05. Result shows that C. hispidum, extract reduced blood glucose level in the test groups as dose of extract increased. C. hispidum, demonstrated hypoglycermic effect. Biochemical indices shows safety of liver, kidney and heart cells.

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