World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF BIOCHEMICAL PARAMETER AND HYPOGLYCERMIC POTENTIAL OF COMBRETUM HISPIDUM.LAW ROOT EXTRACT ON ALLOXAN INDUCED DIABETES IN RATS

O. V. Ikpeazu*, K. K. Igwe and I. E. Otuokere

ABSTRACT

Antidiabetic activity of Combretum hispidum, was checked. Twenty-five rats were used for the research and were grouped into five of five rats each. Groups 1 was the untreated diabetic group while groups 2, 3 and 4 were the treatment which received 200, 400 and 800 mg/kg body weight of the C. hispidum extract respectively. Group 5 was the positive control and was administered known antidiabetic drug Glibenclamide. Diabetes was induced in the rats with alloxan monohydrate. C. hispidum, extract was administered to rats for 14 days orally by intubation, thereafter were sacrificed and blood collected from heart for analysis. Effect of C. hispidum, extract was checked on blood glucose level for possible hypoglycermic potential and biochemical parameters. All results in treatment groups were compared with the untreated diabetic group at statistical confidence of p<0.05.This significant effect was recorded at Day 1, Day 3 and Day 7 of the treatment. Result shows that C. hispidum extract reduced blood glucose level in the test groups as dose of extract increased. C. hispidum, demonstrated hypoglycermic effect. Biochemical indices indicated safety of liver, kidney cardiac cells.

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