World Journal of
Pharmaceutical and Life Sciences

JOURNAL OF PHARMACOLOGY AND LIFE SCIENCE PAPER 2 (2020) BIOCHEMICAL INDICES AND HYPOGLYCERMIC EFFECT OF ETHANOL LEAF EXTRACT OF COMBRETUM HISPIDUM.LAW ON ALLOXAN INDUCED DIABETIC RATS

O. V. Ikpeazu*, K. K. Igwe and I. E. Otuokere

ABSTRACT

Antidiabetic activity of Combretum hispidum, was checked. Twenty-five rats were used for the research were grouped into five of five rats each. Groups 1 was the untreated diabetic group, 2, 3 and 4 were the treatment groups which received 200, 400 and 800 mg/kg body weight of the C. hispidum, leaf extract. Group 5 was the positive control and was administered known antidiabetic drug Glibenclamide. Diabetes was induced in the rats with alloxan monohydrate. C. hispidum, extract was administered to rats for 14 days orally by intubation, thereafter were sacrificed and blood collected from heart for analysis. Effect of C. hispidum, extract was checked on blood glucose level and Biochemical indices. All results in treatment groups were compared with the untreated diabetic group at statistical confidence of p<0.05. Result shows that C. hispidum, leaf extract reduced blood glucose level in the test groups as dose of extract increased. C. hispidum, leaves demonstrated hypoglycermic effect. Biochemical indices indicated liver, kidney and cardiac protective effect.

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