World Journal of
Pharmaceutical and Life Sciences

DESIGN AND STANDARDIZATION OF TRANSDERMAL PATCHES USING OPIATE ANALGESIC DRUG

D. Amulya*, Dr. P.V. Murali Krishna, Kolavali Yalla Reddy, J. Praveen Kumar and Sai Koteswar Sarma

ABSTRACT

The aim of the current study was to design a transdermal patch of opiate analgesic drug. It is a painkiller belonging to the class of opioids that act on the central nervous system. It can be defined as the passage of a medicament from the outside of the skin through its various layers into the bloodstream. Transdermal patches of Tramadol HCl were designed by solvent mercury casting method using different polymers i.e. HPMC, PVA, mixture of HPMC ? PVA. The prepared formulations were standardized for drug content uniformity, in vitro diffusion study, thickness, tensile strength, moisture content, folding endurances etc. Amongst all formulations, formulation F3 had more desirable characteristic & shows longer duration of time. The Transdermal patch formulated from F1, F2 and F3 showed satisfactory physicochemical properties. The ratios of hydrophilic polymers F1, F2 and F3 formulations good moisture content property, good tensile strength, folding endurances and in-vitro drug release. So, it can be concluded that transdermal patches of F1, F2 and F3 could be a good carrier in transdermal delivery of Tramadol HCl. FTIR studies showed there were no incompatibilities between drug and other excipients.

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