World Journal of
Pharmaceutical and Life Sciences

ANXIOLYTIC PROPERTY OF HYDRO-ALCOHOL EXTRACT OF MORINGA OLEIFERA AND ITS EFFECT ON BEHAVIORAL ACTIVITIES OF RAT

Bakou Niangoran François*, B. A. Abdoulaye, Guiro Hamidou and Atayi E.

ABSTRACT

Objective: The aim of the present work is to evaluate the anxiolytic effect of hydroalcoholic extract of leaves from Moringa oleifera in rat. Materials and Methods: The hole-board test, elevated plus-maze paradigm and open field test, were used to assess the anxiolytic activity of hydroalcoholic extract of leaves from Moringa oleifera. The extract of Moringa oleifera (5, 10, and 25mg/kg, i.p.) and diazepam (1 mg/kg, i.p.) were administered 30 min before the tests. Results: The results showed that extract of Moringa oleifera (10 and 25 mg/kg, i.p) significantly increased the number and duration of head poking in the hole-board test. In the elevated plus-maze, the extract significantly increased the exploration of the open arm in similar way to that of diazepam. At a dose of 10 and 25 mg/kg i.p. the extract significantly increased both the time spent in and the entries into the open arm by rat. Further, in the open field test, the extract significantly increased rearing, assisted rearing, and number of squares traversed, all of which are demonstrations of exploratory behavior. Conclusion: The results of the present study suggest that a hydroalcoholic extract of Moringa oleifera leaves may possess an anxiolytic effect.

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