World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

IDENTIFICATION OF PUTATIVE MicroRNAs FOR EARLY DETECTION OF HEPATOCARCINOMA

Shivani Priya and Lakhan Kma*

ABSTRACT

Hepatocellular carcinoma is most prevalent and life threatening cancer. Its early diagnosis and metastasis monitoring are of the utmost importance. With the advance in understanding of tumor biology along with advance development of cellular and molecular techniques, the role of biomarkers related to early detection, invasiveness, metastasis and recurrence has increased the interest of research resulting in discovery and utilization of several novel markers. In present review, cellular and molecular changes in HCC along with some reported serum marker including miRNAs are summarized. Furthermore tumor suppressive and tumor promoting roles and underlying mechanism of miRNAs in HCC are discussed.

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