World Journal of
Pharmaceutical and Life Sciences

EFFECT OF VITAMIN D AND MELATONIN SUPPLEMENTATION AS ADJUVANT IN TREATMENT OF NEONATAL JAUNDICE

*Dr. Zahrah Mohammed Ali Abbood Issa, Booran Mamdooh Saeed Nazhat and Rand A. Abduljabbar Al-Wattar

ABSTRACT

In newborn babies and neonates, neonatal jaundice is a common problem which is treated by different methods to avoid the development of complication especially bilirubin encephalopathy or kernicterus. This prospective clinical trial was done during the period from July 2016 to January 2018 in Al-Karama hospital in Baghdad/Iraq on 120 neonates suffering from neonatal jaundice. The studied neonates were divided into 3 groups: Group (1) who were treated by vitamin D and phototherapy, group (2) who were treated by melatonin and phototherapy and group (3) who were treated by phototherapy alone. Results showed that serum bilirubin was significantly declined in neonates of group (1) who were treated by vitamin D and phototherapy, compared with neonates of group (2) and (3) who were treated with combined melatonin with phototherapy and phototherapy respectively with p-value equal 0.002 and 0.001 respectively. There was a significant decrease in serum bilirubin levels in neonate of group (2) who were treated with melatonin and phototherapy when compared with group (3) who was treated by phototherapy alone with p-value equal 0.002. It can be concluded that Vitamin D and melatonin could be used as adjuvant treatments in neonatal jaundice in combination with phototherapy with superiority of vitamin D over melatonin.

[Full Text Article]   [Download Certificate]